triglycerides in the blood. Having several of these problems is called metabolic syndrome or insulin resistance syndrome, formerly called syndrome X....Insulin resistance is a condition in which the body produces insulin but does not use it properly. Insulin, a hormone made by the pancreas, helps the body use glucose for energy. Glucose is a form of sugar that is the body’s main source of energy. The body’s digestive system breaks food down into glucose, which then travels in the bloodstream to cells throughout the body. Glucose in the blood is called blood glucose, also known as blood sugar. As the blood glucose level rises after a meal, the pancreas releases insulin to help cells take in and use the glucose....

OBJECTIVEdAlthough insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory ...Depressive symptoms are associated with type 2 diabetes (1) and the metabolic syndrome (2,3), and insulin resistance (IR) is thought to be the underlying factor. However, previous findings have been conflicting because depressive symptoms have been reported to be associated with both higher IR (4) and lower IR (5), whereas some studies have reported null associations (6,7). We examined associations of depressive symptoms with IR and insulin secretion in individuals without diabetes....

Far too many care providers refuse to believe that these conditions exist, in spite of all the research to the contrary. Reactive hypoglycemia is not the same as fasting hypoglycemia, which is low blood sugar that occurs when you don’t eat. Reactive hypoglycemia is not always picked up on routine medical tests. It usually occurs two to three hours after a high carbohydrate meal, overstimulating the release of insulin, which triggers a compensatory adrenalin response. Hypoglycemia appears to induce abnormalities in decision-making processes (Blackman, Towle, Lewis et al. 1990) and can contribute to our fibrofog. Some symptoms of hypoglycemia (tremor, palpitations, anxiety, sweating, hunger, paresthesias) are due to changes caused by the response of the autonomic nervous system. Other symptoms (confusion, sensation of warmth, weakness or fatigue, severe cognitive failure, seizure, coma) are the results of brain glucose deprivation itself (Cryer, 1999). Coexisting RHG makes treatment of FMS and CMP extremely difficult. Myofascial TrP activity is so aggravated by it that it doesn’t make sense to treat TrPs unless the hypoglycemia is treated also (Simons 1989). When your body no longer responds appropriately to the insulin that you produce, you have developed IR. Insulin resistance can be serious. Activation of the HPA axis and the central sympathetic nervous system can cause endocrine abnormalities, insulin resistance, and other symptoms leading to disease states, including Type 2 diabetes (Bjorntorp, Holm and Rosamund, 1999). Normal blood sugar levels with coexisting high insulin, associated with obesity or problems in fat metabolism, could be considered as "normoglycemic diabetes", which will develop in time toward hyperglycemia (Ionescu-Tirgoviste, 1998)....ties, insulin resistance, and other symptoms leading to disease states, including. Type 2 diabetes (Bjorntorp, Holm and Rosamund, 1999). Normal blood sugar ...

Polycystic Ovary Syndrome (PCOS), Insulin Resistance (IR), Type 2 Diabetes, & the Metabolic. Syndrome are common conditions, frequently in the news ...What is Polycystic Ovary Syndrome (PCOS)? PCOS is a common endocrine disorder, occurring in about 5% of reproductive-aged women (1). PCOS is a syndrome, not a specific disease. In medicine, a syndrome is a group of symptoms & signs that are recognized to be associated with each other but are without an understood common cause as is known to diseases. (For example, in most cases, high blood pressure [hypertension] is really part of a syndrome; it is associated with being overweight, not exercising, ethnicity, & age. However, rare cases of hypertension can be caused by a specific disease such as narrowing of the artery to the kidney – in this case, the hypertension can be cured by a specific treatment [widening the artery].)...

To understand the autoimmune mediated insulin resistance syndrome. CASE PRESENTATION. PC is a 68-year-old female with a history Hashimoto's thyroiditis ...PC is a 68-year-old female with a history Hashimoto’s thyroiditis and mixed connective tissue disorder who developed rapid-onset, difficult to control diabetes mellitus. Several months before admission, she developed progressive weakness, polyuria leading to incontinence, polydypsia, and polyphagia, and had noted a 50 lb. weight loss. She also developed acanthosis nigricans in her inguinal and axillary regions and lower extremity paresthesias. She visited her PMD and was noted to have elevated serum blood glucose. She was started on oral hypoglycemic medications, but despite maximum doses of metformin, pioglitazone, and glipizide, she was unable to accomplish satisfactory glycemic control. She was started on subcutaneous insulin four months before her admission, but required ever increasing doses. Immediately prior to admission, she was receiving a total of 500 units of subcutaneous insulin daily, and her serum blood glucose readings were in the 400-500 mg/dL range....